Scientists Successfully Synthesized the Prions

Sometimes in order to understand the mechanism of something, related information needs to be rebuilt; it is also true for prions. Recently, researchers from the Institute of Milan BESTA have successfully assembled artificial prions after mass trails, and at the same time they also devised a way to synthesize prions. Laboratory testing results indicate that the synthetic prions can show similar biological characteristics; relevant research results have been published in the international journals.

Researchers noted the study will help people understand a fact that prions can also cause disease, such as the molecular mechanisms of disease processes like BSE and Creutzfeldt-Jakob disease. Synthetic prions could help researchers to conduct experiments on pathogenic reactions, enabling an accurate control. But the operation of natural prions is not so easy because such prions are very complex and heterogeneous. 

Researchers can easily control the heterogeneity and structural characteristics of those synthetic prions, and these synthetic virus will exhibit the same sequence as natural virus. Clearly, the ultimate goal of researchers is to identify how to block prions infection and develop new therapies to resist the occurrence of related diseases. In this study, researchers first successfully synthesized the prions in mice and identified involved molecular mechanism in mice caused by pathogenic prions, which might help understand the pathogenesis of natural prions. When they are analyzing the specific features of prion properties, they have found synthetic prions that could cause BSE and CJD are very similar to natural prions. 

The researchers concluded that such research has been carried out for a long time and the in-depth discovery will be completed in the future, which will probably promote natural prions research on humans. Currently, the study has benefited the development of new therapies for human neurodegenerative prion-caused disease. In addition, researchers are considering whether it’s available to synthesize key molecules that cause Parkinson’s disease or amyloid triggering Alzheimer’s disease, which could help develop new therapies to treat diseases such as neurodegenerative disorders. 

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